| Pair Name | Oxymatrine, Fluorouracil | ||
| Phytochemical Name | Oxymatrine (PubChem CID: 114850 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Oxymatrine, Fluorouracil | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Biological Phenomena | Inhibition-->Epithelial-mesenchymal transition | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Up-regulation | Expression | CDH1 | hsa999 | |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| Down-regulation | Expression | SNAI2 | hsa6591 | |
| Down-regulation | Expression | VIM | hsa7431 | |
| In Vitro Model | HCT 8 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_2478 |
| Result | Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-kappa B signaling in vitro | |||
| No. | Title | Href |
|---|---|---|
| 1 | Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-κB signaling in vitro. Oncol Lett. 2020 Jan;19(1):519-526. doi: 10.3892/ol.2019.11090. | Click |
